wezterm can also connect to serial ports as a client. This is useful for example when working with embedded devices such as Arduino, or when connecting to a serial console on a headless server.
For example, on Linux:
$ wezterm serial /dev/ttyUSB0
or on Windows:
$ wezterm serial COM0
You can also specify the baud rate:
$ wezterm serial --baud 38400 /dev/ttyUSB0
When a wezterm window is operating in serial mode it is not possible to create new tabs.